Thioacetamide-Induced Changes in Diploid Cultures of Human Liver
نویسندگان
چکیده
منابع مشابه
Experimental thioacetamide-induced cirrhosis of the liver.
Hepatic cirrhosis is a complex disease in which several biological, biochemical and chemical alterations are combined, none of these alone being sufficient for diagnosis. The morphological characteristics of the final stages of cirrhosis are well known, but the initial lesions and intermediate stages still have not been fully clarified. An experimental model of hepatic cirrhosis by chronic admi...
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The present study determined the regenerative effect of bone marrow-derived stem cells (BMSCs) on thioacetamide (TA)-induced liver fibrosis in rats. A total of 30 male Wistar rats were randomly divided into sham control and treatment groups. The rats of the sham control group were subdivided into three groups and sampled on the 14th, 18th, and 20th weeks after fibrosis induction. The rats of th...
متن کاملThe Effect of Hydroalcoholic Extract of Tamarix dioica Flower on Thioacetamide - Induced Histomorphological Changes in Rats
Background and Objectives: The present experimental study was aimed to investigate the effect of T. dioica flower hydroalcoholic extract on thioacetamide induced histopathological changes. Methods: Thirty adult male Wistar rats, were randomly divided into three groups of control (normal saline); negative control (thioacetamide 50 mg/kg) and group that received thioacetamide and T. dioica flo...
متن کاملSerum amino acid changes in rats with thioacetamide-induced liver cirrhosis.
To date, no attempt has been made to study alterations occurring in the amino acid profile in chronic models of thioacetamide-induced liver cirrhosis. In this work, changes in serum amino acids and proteins in rats with thioacetamide-induced liver cirrhosis are reported, together with changes in enzyme activities in the liver and serum. Seventeen female Wistar rats were used. Eight rats were gi...
متن کاملEarly changes in rat liver and kidney cells induced by thioacetamide.
Thioacetamide (TA), a drug effective in the control of orange decay (5), was found to induce liver cirrhosis, tumors (9), and cancer of the bile ducts (11) if fed to rats over a period of several months. The most striking effects, first described by Rather (28), are the doubling of nuclear vol ume, increased nucleolar and cell volumes, and altered basophilia of the cytoplasm. These changes are ...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy
سال: 1976
ISSN: 0021-4280
DOI: 10.2183/pjab1945.52.195